Cognitive Exercise for Postoperative Recovery​

April 9, 2025

Cognitive function is often overlooked in the postoperative recovery process, yet many patients experience cognitive changes after surgery, including memory lapses, difficulty concentrating, and confusion (Nilsson, 2019). This phenomenon, known as postoperative cognitive dysfunction (POCD), is a significant concern for older adults in particular. Studies indicate that POCD affects approximately 36.6% of young adults and 42.4% of older individuals following surgery (Varpaei et al., 2024). These cognitive impairments can slow recovery, prolong hospital stays, and increase the risk of long-term complications (Fogg et al., 2018). Researchers are now investigating non-pharmacological interventions—namely, cognitive exercise—to help patients maintain and restore cognitive function during postoperative recovery (Zhao et al., 2024).

Cognitive exercise refers to structured mental activities that stimulate neuroplasticity, strengthen neural connections, and improve cognitive performance. Similar to how physical rehabilitation aids mobility recovery, cognitive exercise can help patients restore mental sharpness and reinforce neural networks that support cognitive processes during postoperative recovery (Kumar et al., 2023). It mitigates the effects of POCD by leveraging the brain’s ability to reorganize and adapt in response to experience (Kotekar et al., 2018). Engaging in structured cognitive exercise enhances neural pathways, reinforcing existing connections while forming new ones (Kumar et al., 2023).

Cognitive exercises used in postoperative recovery programs typically involve structured activities that engage multiple cognitive domains (Berger et al., 2015). Activities such as puzzles and brain games challenge problem-solving abilities and improve concentration. Attention and processing speed exercises, often implemented through computerized training programs, help improve reaction times and focus (Maggio et al., 2023). These activities collectively contribute to cognitive rehabilitation, which involves methods for retraining neural pathways to regain or improve neurocognitive functioning diminished by disease or trauma.

Another critical factor in cognitive resilience is cognitive reserve, which refers to the brain’s ability to withstand damage and maintain function despite stressors such as surgery (Kainz et al., 2023; Feinkohl et al., 2017). Individuals with more significant cognitive reserve, often developed through lifelong learning and mental stimulation, demonstrate lower rates of cognitive impairment following surgery (Kainz et al., 2023; Feinkohl et al., 2017).

A randomized controlled trial investigating cognitive training in cardiac surgery patients found that those who engaged in daily cognitive exercise during their postoperative recovery period had significantly lower POCD rates than those receiving standard care (Zhang et al., 2024). By the time of hospital discharge, only 19% of patients in the cognitive training group exhibited cognitive decline, compared to 50% in the control group (Butz et al., 2022). These benefits persisted three months after surgery, highlighting the potential for cognitive training to provide long-lasting improvements in cognitive function (Butz et al., 2022; Zhang et al., 2024).

Cognitive exercise is emerging as a safe, non-invasive, and cost-effective tool to enhance postoperative recovery. Postoperative recovery presents an opportunity to reinforce brain function through structured mental exercises, ultimately benefiting patients beyond immediate cognitive performance and improving their ability to return to daily activities (Powell et al., 2016). Integrating cognitive training into postoperative recovery requires careful consideration of timing and individual patient needs (Ishizawa, 2022). Research suggests cognitive exercise should begin once patients are medically stable and their pain is adequately controlled (Zhao et al., 2024). By incorporating mental training alongside physical rehabilitation, patients may reduce cognitive decline, maintain independence, and improve overall quality of life following surgery.

References

Berger, M., Nadler, J. W., Browndyke, J., Terrando, N., Ponnusamy, V., Cohen, H. J., Whitson, H. E., & Mathew, J. P. (2015). Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly. Anesthesiology clinics33(3), 517–550. https://doi.org/10.1016/j.anclin.2015.05.008

Butz, M., Gerriets, T., Sammer, G., El-Shazly, J., Tschernatsch, M., Huttner, H. B., Braun, T., Boening, A., Mengden, T., Choi, Y. H., Schoenburg, M., & Juenemann, M. (2022). Effects of postoperative cognitive training on neurocognitive decline after heart surgery: a randomized clinical trial. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery62(5), ezac251. https://doi.org/10.1093/ejcts/ezac251

Feinkohl, I., Winterer, G., Spies, C. D., & Pischon, T. (2017). Cognitive Reserve and the Risk of Postoperative Cognitive Dysfunction. Deutsches Arzteblatt international114(7), 110–117. https://doi.org/10.3238/arztebl.2017.0110

Fogg, C., Griffiths, P., Meredith, P., & Bridges, J. (2018). Hospital outcomes of older people with cognitive impairment: An integrative review. International journal of geriatric psychiatry33(9), 1177–1197. Advance online publication. https://doi.org/10.1002/gps.4919

Ishizawa Y. (2022). Does Preoperative Cognitive Optimization Improve Postoperative Outcomes in the Elderly?. Journal of clinical medicine11(2), 445. https://doi.org/10.3390/jcm11020445

Kainz, E., Juilfs, N., Harler, U., Kahl, U., Mewes, C., Zöllner, C., & Fischer, M. (2023). The impact of cognitive reserve on delayed neurocognitive recovery after major non-cardiac surgery: an exploratory substudy. Frontiers in aging neuroscience15, 1267998. https://doi.org/10.3389/fnagi.2023.1267998

Kotekar, N., Shenkar, A., & Nagaraj, R. (2018). Postoperative cognitive dysfunction – current preventive strategies. Clinical interventions in aging13, 2267–2273. https://doi.org/10.2147/CIA.S133896

Kumar, J., Patel, T., Sugandh, F., Dev, J., Kumar, U., Adeeb, M., Kachhadia, M. P., Puri, P., Prachi, F., Zaman, M. U., Kumar, S., Varrassi, G., & Syed, A. R. S. (2023). Innovative Approaches and Therapies to Enhance Neuroplasticity and Promote Recovery in Patients With Neurological Disorders: A Narrative Review. Cureus15(7), e41914. https://doi.org/10.7759/cureus.41914

Maggio, M. G., De Bartolo, D., Calabrò, R. S., Ciancarelli, I., Cerasa, A., Tonin, P., Di Iulio, F., Paolucci, S., Antonucci, G., Morone, G., & Iosa, M. (2023). Computer-assisted cognitive rehabilitation in neurological patients: state-of-art and future perspectives. Frontiers in neurology14, 1255319. https://doi.org/10.3389/fneur.2023.1255319

Nilsson, U., Liander, K., Rooyackers, O., & Eriksson, L. I. (2019). Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study. BMJ open9(12), e032650. https://doi.org/10.1136/bmjopen-2019-032650.

Powell, R., Scott, N. W., Manyande, A., Bruce, J., Vögele, C., Byrne-Davis, L. M., Unsworth, M., Osmer, C., & Johnston, M. (2016). Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia. The Cochrane database of systematic reviews2016(5), CD008646. https://doi.org/10.1002/14651858.CD008646.pub2

Varpaei, H. A., Farhadi, K., Mohammadi, M., Khafaee Pour Khamseh, A., & Mokhtari, T. (2024). Postoperative cognitive dysfunction: a concept analysis. Aging clinical and experimental research36(1), 133. https://doi.org/10.1007/s40520-024-02779-7

Zhang, R., Zhu, C., Chen, S., Tian, F., Huang, P., & Chen, Y. (2024). Effects of cognitive training on cognitive function in patients after cardiac surgery: A systematic review and meta-analysis of randomized controlled trials. Medicine103(44), e40324. https://doi.org/10.1097/MD.0000000000040324

Zhao, L., Guo, Y., Zhou, X., Mao, W., Zhu, H., Chen, L., Liu, X., Zhang, L., Xie, Y., & Li, L. (2024). The research progress of perioperative non-pharmacological interventions on postoperative cognitive dysfunction: a narrative review. Frontiers in neurology15, 1369821. https://doi.org/10.3389/fneur.2024.1369821